General Information

  • ID:  hor001700
  • Uniprot ID:  B0M3D5
  • Protein name:  Extended FMRFamide-12
  • Gene name:  NA
  • Organism:  Mantophasma kudubergense (Gladiator) (Heel-walker)
  • Family:  FARP (FMRF amide related peptide) family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Mantophasma (genus), Mantophasmatidae (family), Mantophasmatodea (order), Polyneoptera (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  SPGALEDEHNDNFLRF
  • Length:  16
  • Propeptide:  SPGALEDEHNDNFLRF
  • Signal peptide:  NA
  • Modification:  T16 Phenylalanine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  FMRFamides and FMRFamide-like peptides are neuropeptides.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-B0M3D5-F1(AlphaFold_DB_ID)
  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
  •    AF-B0M3D5-F1.pdbhor001700_AF2.pdbhor001700_ESM.pdb

Physical Information

Mass: 212869 Formula: C81H117N23O28
Absent amino acids: CIKMQTVWY Common amino acids: DEFLN
pI: 4.1 Basic residues: 2
Polar residues: 4 Hydrophobic residues: 5
Hydrophobicity: -103.13 Boman Index: -4877
Half-Life: 1.9 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 55
Instability Index: 5630 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  22508719
  • Title:  Peptidomics-based phylogeny and biogeography of Mantophasmatodea (Hexapoda).